Hemophagocytic Lymphohistiocytosis (HLH) is a rare but potentially fatal disease of normal but overactive histiocytes and lymphocytes that commonly appears in infancy, although it has been seen in all age groups. Fever, Hepatosplenomegaly, Pancytopenia, Lymphadenopathy, and rash often comprise the initial presentation. Primary HLH also occurs in some closely related inherited diseases.

X-rays, CT scans, ultrasounds or MRIs may be performed.

Signs and Symptoms of HLH may include :



• Fever
• Jaundice
• Persistent Fevers
• Low Platelets
• Anemia
• Enlarged Spleen
• Low White Blood Cells
• Liver Failure
• Skin Rashes

Treatments for HLH may include :



• Chemotherapy
• Steroids
• Antiviral drugs
• Antibiotic drugs

There is no way to prevent HLH, but as healthcare providers continue to learn more about it, treatment improves. Most children who are successfully treated go on to live normal lives.